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Antigenic Specificity | Histone H3 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of Histone H3. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. This Ant |
Immunogen | n/a |
Other Names | [histone H3.1; Histone H3.1; histone H3.1; histone cluster 1 H3 family member a; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l], [HIST1H3A; HIST1H3A; H3/A; H3FA; H3FA] |
Gene, Accession # | Gene ID: 8350, NCBI: NP_003520.1, UniProt: P68431 |
Catalog # | MBS857142 |
Price | $280 |
Order / More Info | Histone H3 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Flanagan J.F., Mi L.-Z., Chruszcz M., Cymborowski M., Clines K.L., Kim Y., Minor W., Rastinejad F., Khorasanizadeh S.Double chromodomains cooperate to recognize the methylated histone H3 tail.Nature 438:1181-1185(2005). 2. Arginine methylation of the histone H3 tail impedes effector binding.Iberg A.N., Espejo A., Cheng D., Kim D., Michaud-Levesque J., Richard S., Bedford M.T.J. Biol. Chem. 283:3006-3010(2008). |