Histone H3 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityHistone H3
Clonepolyclonal
Host Speciesn/a
Reactive Specieshuman, mouse, rat
Isotypen/a
Formataffinity purified
Size0.1 mL
Concentrationn/a
ApplicationsWestern Blot (WB)
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DescriptionThis antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of Histone H3. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. This Ant
Immunogenn/a
Other Names[histone H3.1; Histone H3.1; histone H3.1; histone cluster 1 H3 family member a; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l], [HIST1H3A; HIST1H3A; H3/A; H3FA; H3FA]
Gene, Accession #Gene ID: 8350, NCBI: NP_003520.1, UniProt: P68431
Catalog #MBS857142
Price$280
Order / More InfoHistone H3 Antibody from MYBIOSOURCE INC.
Product Specific References1. Flanagan J.F., Mi L.-Z., Chruszcz M., Cymborowski M., Clines K.L., Kim Y., Minor W., Rastinejad F., Khorasanizadeh S.Double chromodomains cooperate to recognize the methylated histone H3 tail.Nature 438:1181-1185(2005). 2. Arginine methylation of the histone H3 tail impedes effector binding.Iberg A.N., Espejo A., Cheng D., Kim D., Michaud-Levesque J., Richard S., Bedford M.T.J. Biol. Chem. 283:3006-3010(2008).
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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