Edit |   |
---|---|
Antigenic Specificity | CD41 |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
Immunogen | Immunogen: A synthesized peptide derived from human CD41. Subcellular Localization: Membrane; Single-pass type I membrane protein. Tissue Specificity: Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells. |
Other Names | [Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41; Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain; form 1; Integrin alpha-IIb light chain; form 2; ITGA2B; GP2B; ITGAB], [ITGA2B] |
Gene, Accession # | [CD41], Gene ID: 3674, NCBI: NP_000410.2, UniProt: P08514 |
Catalog # | MBS179555 |
Price | $160, $340, $340 |
Order / More Info | CD41 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |