N-Cadherin (Cytoplasmic) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | N-Cadherin (Cytoplasmic) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human, rat, mouse |
| Isotype | IgG1 |
| Format | Protein A purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA, Western Blot, Immunocytochemistry, Immunoprecipitation |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This N-cadherin antibody detects a 130 kDa* protein in human Skn-SH and endothelial cells, as well as mouse brain tissue and C2C12 cells. The antibody does not cross-react with E-cadherin or VE-cadherin. Cadherins are transmembrane glycoproteins vital in calcium-dependent cell-cell adhesion during tissue differentiation. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the cadherin-mediated adhesion may be by the juxtamembrane region in cadherins. This region induces clustering and also binds to the protein p120 catenin. The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin, |
| Immunogen | Immunogen: Clone (M170) was generated from a human recombinant N-Cadherin protein containing amino acids in the C-terminal region. This sequence is highly conserved in rat and mouse N-Cadherin, and has some homology to R-cadherin. |
| Other Names | [Cadherin-2; Neural-Cadherin; CD325 antigen], [CDH2; CDH2; CDHN; NCAD; CD325; CDw325; CDHN; NCAD] |
| Gene, Accession # | Gene ID: 1000, UniProt: P19022 |
| Catalog # | MBS470018 |
| Price | $325 |
| Order / More Info | N-Cadherin (Cytoplasmic) Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Xu, Y. et al. (1997) J. Biol. Chem. 272(21):13463• Xu, Y. & Carpenter, G. (1999) J. Cell. Bioch. 75:264• Qi, J. et al. (2006) Mol. Biol. Cell 17(3):1261 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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