ARHGEF4 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | ARHGEF4 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: ARHGEF4 antibody detects endogenous levels of total ARHGEF4. Function: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.Subunit Structure: Isoform 3 interacts with RHOA and RAC1, and (via ABR domain) with APC. Found in a complex consisting of ARHGEF4, APC and CTNNB1.Similarity: In an autoinhibited form the SH3 domain binds intramolecul |
| Immunogen | Immunogen: A synthesized peptide derived from human ARHGEF4 Subcellular Location: Plasma Membrane Tissue Specificity: Expressed at high levels in the brain, skeletal muscle and testis and at low levels in the kidney, lung, small intestine, ovary and prostate. Expression is aberrantly enhanced in most colorectal tumors. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog Similarity: Pig (92%), Bovine (92%), Horse (92%), Sheep (92%), Rabbit (92%), Dog (100%) |
| Other Names | [APC stimulated guanine nucleotide exchange factor 1; APC stimulated guanine nucleotide exchange factor; ARHGEF 4; Asef; ASEF1; GEF 4; GEF; GEF4; KIAA1112; Rho guanine nucleotide exchange factor (GEF) 4; Rho guanine nucleotide exchange factor 4; STM 6; STM6] |
| Gene, Accession # | [ARHGEF4], Gene ID: 50649, NCBI: NP_056135.2, UniProt: Q9NR80 |
| Catalog # | MBS9610180 |
| Price | $240, $280 |
| Order / More Info | ARHGEF4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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