Human Transcriptional repressor CTCFL Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityHuman Transcriptional repressor CTCFL
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatantigen affinity purified
Size0.05 mL, 0.1 mL
Concentrationn/a
ApplicationsELISA (EIA), Immunohistochemistry (IHC)
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DescriptionTestis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for
ImmunogenImmunogen: Recombinant human Transcriptional repressor CTCFL protein(1-270aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-51036 / sc-51039 / sc-51038 / sc-51037 / sc-98982
Other Names[Brother of the regulator of imprinted sites; CCCTC-binding factor; CTCF paralog; CTCF-like protein; Cancer/testis antigen 27; CT27; Zinc finger protein CTCF-T; CTCFL; BORIS], [CTCFL; CTCFL; CT27; BORIS; CTCF-T; HMGB1L1; dJ579F20.2; BORIS; CT27]
Gene, Accession #[CTCFL], Gene ID: 140690, NCBI: NP_001255969.1, UniProt: Q8NI51
Catalog #MBS1496155
Price$120, $160
Order / More InfoHuman Transcriptional repressor CTCFL Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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