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Antigenic Specificity | Rat Aminopeptidase P |
Clone | [IgG1, JG12C9C10] |
Host Species | Mouse |
Reactive Species | rat |
Isotype | IgG1 |
Format | Protein G purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Aminopeptidase P (AP-P; X-Pro aminopeptidase) has the unique ability to leave the N-terminal amino acid residue from peptides having proline as the penultimate amino acid residue. Biologically active peptides comprise an important and diverse class of extracellular chemical messengers that mediate a wide range of intercellular interactions. Several bioactive peptides including hormones, neuropeptides, neurotransmitters escape non-specific protease degradation by having an Xaa-Pro motif at their amino termini. Due to its cyclic nature, proline confers resistance to such peptide bonds so that aminopeptidases with broad specificity cannot act upon such peptides. There are a limited number of peptidases that act on peptide bonds involving a pro |
Immunogen | Immunogen: membrane protein fraction of isolated rat glomeruli. Preparation: Monoclonal antibodies were produced with the help of BALB/c mice using a membrane protein fraction of isolated rat glomeruli as the immunizing antigen. |
Other Names | [rat Aminopeptidase P (#JG12C9C10); X-prolyl aminopeptidese 1; Xaa-Pro-anminopeptidase 1], [Xpnpep1; Xpnpep1; App; sAmp] |
Gene, Accession # | Gene ID: 170751, NCBI: NP_571988.1, UniProt: O54975 |
Catalog # | MBS690410 |
Price | $365 |
Order / More Info | Rat Aminopeptidase P Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Yaron A and Naider F, Crit. Rev. Biochem. Mol. Biol. 28, 31-81 2, 1993 2. Yaron A, Biopolymers 26, S215-S222, 1987 3. Mentlein R, FEBS Lett. 234,251-256, 1988 4. Vanhoof G et al, FASEB J 9, 736-744, 1995 5. Hooper NM et al, Biochem J 267, 509-515, 1990 6. Simmons WH and Orawski AT, J Biol Chem 267, 4897, 1992 7. Rusu I and Yaron A, Eur J Biochem 210, 93-100, 1992 8. Harbeck HT and Mentlein R, Eur J Biochem 198, 451-458, 1991 |