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Antigenic Specificity | MAPT (C-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat (predicted reactivity: bovine) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MAPT antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 694-728 amino acids from the C-terminal region of human MAPT. Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
Immunogen | n/a |
Other Names | [Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPT; MAPTL; MTBT1; TAU] |
Gene, Accession # | [MAPT], Gene ID: 4137, NCBI: NP_001116538.2, UniProt: P10636 |
Catalog # | MBS9211281 |
Price | $165, $370 |
Order / More Info | MAPT (C-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Goedert M.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988). Goedert M.,et al.EMBO J. 8:393-399(1989). Lee G.,et al.Neuron 2:1615-1624(1989). Goedert M.,et al.Neuron 3:519-526(1989). Andreadis A.,et al.Biochemistry 31:10626-10633(1992). |