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Antigenic Specificity | CASP9 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CASP9 Antibody detects endogenous levels of total CASP9. Caspase-9 (ICE-LAP6, Mch6) is an important member of the cysteine aspartic acid protease (caspase) family (1, 2). Upon apoptotic stimulation, cytochrome c released from mitochondria associates with the 47 kDa procaspase-9/Apaf 1. Apaf-1 mediated activation of caspase-9 involves instrinsic proteolytic processing resulting in cleavage at Asp315 and producing a p35 subunit. Another cleavage occurs at Asp330 producing a p37 subunit that can serve to amplify the apoptotic response (3-6). Cleaved caspase-9 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, which leads to apoptosis (7-10). |
Immunogen | Immunogen: Recombinant protein of human CASP9 |
Other Names | [MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6] |
Gene, Accession # | [CASP9], Gene ID: 842, NCBI: NP_001220.2, UniProt: P55211 |
Catalog # | MBS8516490 |
Price | $290 |
Order / More Info | CASP9 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |