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Antigenic Specificity | GFR a-2 (IN) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRα, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently. NTNRα was also termed GDNFRβ, Ret ligand 2 (RETL2) or TGFβ-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRα-2 recently. GFRα-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRα-2, and the Ret PTK form a com |
Immunogen | Immunogen: Peptide corresponding to amino acids 377 to 391 of human GFRalpha;-2. The amino acid sequences of immunogenic peptide are identical to those of mouse and rat. |
Other Names | [GDNFRb (IN); GDNFRbeta (IN); Neurturin receptor alpha; RET ligand 2], [GFRA2; GFRA2; NTNRA; RETL2; TRNR2; GDNFRB; NRTNR-ALPHA; GDNFRB; RETL2; TRNR2; GDNF receptor alpha-2; GDNFR-alpha-2; GFR-alpha-2; GDNFR-beta; NRTNR-alpha; NTNR-alpha] |
Gene, Accession # | [GFR a-2], Gene ID: 2675, NCBI: NP_001158510.1, UniProt: O00451 |
Catalog # | MBS395934 |
Price | $510 |
Order / More Info | GFR a-2 (IN) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |