Edit |   |
---|---|
Antigenic Specificity | Cathepsin D |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The purified antibody detects both the 52 kDa proform and the 34 kDa cleaved fragment of Cathepsin D. Background: Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D |
Immunogen | Immunogen: Synthetic peptide surrounding amino acid 140 of mouse cathepsin D |
Other Names | [CTSD; CLN10; CPSD; MGC2311], [CTSD; CTSD; CPSD; CLN10; HEL-S-130P; CPSD] |
Gene, Accession # | Gene ID: 1509, NCBI: NP_001900.1 |
Catalog # | MBS840224 |
Price | $150, $300 |
Order / More Info | Cathepsin D Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |