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Antigenic Specificity | IP-10, Human |
Clone | 6D4 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a |
Format | biotin conjugate |
Size | 0.05 mg |
Concentration | n/a |
Applications | F, Flow Cytometry (FC/FACS), Immunoassay (IA), Immunofluorescence (IF), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Product Description: The monoclonal antibody 6D4 recognizes human C-X-C motif chemokine 10 (IP-10), a protein of 98 amino acids. IP-10, also known as CXCL10, functions as ligand for the CXCR3 receptor. IP-10 belongs to the alpha-chemokine (C-X-C) family, which can be divided in two subfamilies: (1) potent chemoattractants for neutrophils, like IL-8 and (2) potent chemoattractants for lymphocytes, like the IFN inducible protein (IP)-10. IP-10 is produced by a wide variety of cell types ranging from neutrophils, dendritic cells and monocytes to hepatocytes, endothelial cells and keratinocytes. The cytokine is reported to be involved in a scala of inflammatory pathologies such as HIV, encephalitis, cutaneous T cell lymphoma, chronic hepatitis, |
Immunogen | Immunogen: Recombinant human IP-10 |
Other Names | n/a |
Gene, Accession # | [IP-10] |
Catalog # | MBS584238 |
Price | $315 |
Order / More Info | IP-10, Human Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Hamamdzic, D. et al; Reovirus triggers cell type-specific proinflammatory responses dependent on the autocrine action of IFNβ. Am J Physiol Lung Cell Mol Physiol 2001, 280: L18 2. Giustizieri, M et al; Nitric oxide donors suppress chemokine production by keratinocytes in vitro and in vivo. Am J Path 2002, 161: 1409 3. Bendriss-Vermare, N et al; Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-gamma and Th1 chemokine production. J of Leukoc Biol. 2005, 78: 954 4. Curbishley, S et al; CXCR3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow. Am J Pathol 2005, 167: 887 |