ENaC alpha Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | ENaC alpha |
| Clone | [2G4] |
| Host Species | Mouse |
| Reactive Species | mouse; rat |
| Isotype | IgG2b |
| Format | Protein G purified |
| Size | 0.1 mg |
| Concentration | 1 mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Detects ~85kDa. The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2). ENaCs are composed of three structurally related subunits that form a tetrameric channel, alpha, beta, and gamma. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal l |
| Immunogen | Immunogen: Synthetic peptide from the N-terminal of Rat ENaC alpha (aa. 46-68). Immunogen Species: Rat. Cellular Localization: Apical Cell Membrane. Conjugate: Unconjugated. Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Other Names | [Mouse Rat ENaC alpha IgG2b; SCNN1A; Epithelial Sodium Channel-alpha; Epithelial Sodium Channel alpha; Alpha ENaC 2; Alpha ENaC; Alpha NaCH; Alpha-ENaC; Amiloride sensitive epithelial sodium channel alpha subunit; Amiloride sensitive sodium channel subunit alpha; Amiloride-sensitive sodium channel subunit alpha; ENaCa; ENaCalpha; Epithelial Na(+) channel subunit alpha; Epithelial Na+ channel subunit alpha; FLJ21883; Nonvoltage gated sodium channel 1 subunit alpha; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; SCNN 1; SCNN1; SCNN1A; SCNNA_HUMAN; Sodium channel nonvoltage gated 1 alpha], [Scnn1a; Scnn1a; ENaCA] |
| Gene, Accession # | [ENaC alpha], Gene ID: 25122, NCBI: NP_113736, UniProt: Q6IRJ1 |
| Catalog # | MBS808268 |
| Price | $390 |
| Order / More Info | ENaC alpha Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Kakizoe Y., et al. (2009) J Hpyertens. 27(8): 1679-1689. 2. Gu Y. (2008) J Cell Physiol. 216(2):453-457. 3. Bruns J.B. (2003) Am J Physiol Renal Physiol. 285(4): F600-F609. 4. Mauro T., et al. (2002) J Invest Dermatol. 118(4): 589-594. 5. Elias N., et al. (2007) Am J Physiol Lung Cell Mol Physiol. 293(3): L537-45. 6. Dyka F.M., May C.A. and Enz R. (2005) J Neurochem. 94(1): 120-128. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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