IL-1RII, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | IL-1RII, Human |
| Clone | 8.5 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), Immunoassay (IA), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The antibody reacts specificly with Human IL-1RII. The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1RI and IL-1RII) and the IL-1 receptor accessory protein. The IL-1RII is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1RI. The decoy IL-1RII can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1RII exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells |
| Immunogen | n/a |
| Other Names | [interleukin-1 receptor type II; interleukin-1 receptor type II], [IL-1RII] |
| Gene, Accession # | [IL-1RII], Gene ID: 100033831, NCBI: NP_001075285.1 |
| Catalog # | MBS584272 |
| Price | $520 |
| Order / More Info | IL-1RII, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Mantovani, A et al; Regulation of inhibitory pathways of the Interleukin-1 system. Ann N Y Acad Sci 1998, 840: 338 2. Penton-Rol, G et al; Bacterial lipopolysaccharide causes rapid shedding, followed by inhibition of mRNA expression, of the IL-1 type II receptor, with concomitant up-regulation of the type I II receptor and induction of incompletely spliced transcripts. J Immunol 1999, 162: 2931 3. Muller, B et al; High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration. J Leukoc Biol 2002, 72: 643 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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