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Antigenic Specificity | VRK1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of VRK1 protein. VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. VRK1 is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. VRK1, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. |
Immunogen | Immunogen: Synthesized peptide derived from part region of human VRK1 protein |
Other Names | [Rabbit VRK1; Serine/threonine-protein kinase VRK1; Vaccinia-related kinase 1] |
Gene, Accession # | [VRK1], Gene ID: 7443, NCBI: AAI13511.1, UniProt: Q99986 |
Catalog # | MBS9711424 |
Price | $130, $220, $325 |
Order / More Info | VRK1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |