Phospho-p130 Cas (Tyr267) Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPhospho-p130 Cas (Tyr267)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, ratpredicted: porcine, zebrafish, bovine, horse, sheep, rabbit, chicken, Xenopus
Isotypen/a
Formatpeptide affinity purified
Size0.05 mL, 0.1 mL, 0.2 mL
Concentration1mg/ml
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC), Peptide ELISA (EIA)
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DescriptionSpecificity: Phospho-p130 Cas (Tyr267) Antibody detects endogenous levels of p130 Cas only when phosphorylated at Tyr267. Description: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.Post Translational Modifications: PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matri
ImmunogenImmunogen: A synthesized peptide derived from human p130 Cas around the phosphorylation site of Tyr267. Tissue Specificity: Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.
Other Names[BCAR 1; Bcar1; BCAR1_HUMAN; Breast cancer estrogen resistance 1; Breast cancer estrogen resistance 1 protein; Breast cancer estrogen resistance protein 1; CAS; Cas scaffolding protein family member 1; CAS1; Cass1; Crk associated substrate; Crk associated substrate p130Cas; CRK-associated substrate; CRKAS; FLJ12176; FLJ45059]
Gene, Accession #[p130cas], Gene ID: 9564, NCBI: NP_001164185.1, UniProt: P56945
Catalog #MBS9610688
Price$225, $280, $340
Order / More InfoPhospho-p130 Cas (Tyr267) Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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