PRDM2 (RIZ1), 1-347 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | PRDM2 (RIZ1), 1-347 |
| Clone | [33AT1045] |
| Host Species | Mouse |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | n/a |
| Applications | Chromatin Immunoprecipitation (ChIP), Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Purified recombinant GST fusion protein encoding aa 1-347 of human RIZ1. This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2). This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multipl |
| Immunogen | n/a |
| Other Names | [PR domain zinc finger protein 2; GATA-3-binding protein G3B; Lysine N-methyltransferase 8; MTB-ZF; MTE-binding protein; PR domain-containing protein 2; Retinoblastoma protein-interacting zinc finger protein; Zinc finger protein RIZ; PRDM2; KMT8; RIZ] |
| Gene, Accession # | [PRDM2], Gene ID: 7799, NCBI: NP_001007258.1, UniProt: Q13029 |
| Catalog # | MBS9200420 |
| Price | $165, $370 |
| Order / More Info | PRDM2 (RIZ1), 1-347 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Genotypes and haplotypes of the estrogen receptor genes, but not the retinoblastoma-interacting zinc finger protein 1 gene, are associated with osteoporosis. HarslTHf T, et al. Calcif Tissue Int, 2010 Jul. PMID 20508921. DNA methylation of the RIZ1 tumor suppressor gene plays an important role in the tumorigenesis of cervical cancer. Cheng HY, et al. Eur J Med Res, 2010 Jan 29. PMID 20159667. Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. de Vogel S, et al. Cancer Epidemiol Biomarkers Prev, 2009 Nov. PMID 19843671. Expression of RIZ1 protein (Retinoblastoma-interacting zinc-finger protein 1) in prostate cancer epithelial cells changes with cancer grade progression and is modulated in vitro by DHT and E2. Rossi V, et al. J Cell Physiol, 2009 Dec. PMID 19746436. RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression. Lakshmikuttyamma A, et al. J Hematol Oncol, 2009 Jul 14. PMID 19602237. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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