TLR2, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | TLR2, Human |
| Clone | TL2.1 |
| Host Species | Mouse |
| Reactive Species | human, dog, cynomolgus monkey, monkey, rhesus monkey |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 0.5 mg |
| Concentration | n/a |
| Applications | Immunohistochemistry (IHC) Formalin/Paraffin, Flow Cytometry (FC/FACS), Functional Studies (FS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The monoclonal antibody TL2.1 recognizes human Toll-like receptor 2 (TLR2, CD282). Toll-like receptors (TLR) are highly conserved throughout evolution and are involved in the innate defence to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defences. In mammals, TLRs are identified as type I transmembrane signaling receptors with pattern recognition capabilities. They have been implicated in the innate host defence to pathogens. TLR2 is expressed on macrophages, smooth muscle, lung, spleen, thymus, brain and adipose tissue. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of Gram-negative bacteria, sever |
| Immunogen | Immunogen: Recombinant human TLR2 produced by the CHO/CD14 reporter cell line |
| Other Names | [Toll-Like receptor 2; CD282; TLR2], [TLR2; TLR2; TIL4; CD282; TIL4] |
| Gene, Accession # | [TLR2], Gene ID: 7097, NCBI: AKI71244.1 |
| Catalog # | MBS584737 |
| Price | $1215 |
| Order / More Info | TLR2, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Lien, E et al; Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 1999, 274: 33419 2. Flo, T et al; Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol 2001, 69: 474 3. Faure, E et al; Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappaB activation. J Immunol 2001, 166: 2018 4. Droemann, D et al; Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung. Histochem Cell Biol 2003, 119: 103 5. Burgener, I et al; Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol 2008, 124; 184 6. Elsori, D et al; Protein kinase C is a critical component of Dectin-1 signaling in primary human monocytes. J Leukoc Biol 2011, 90: 599 7. Gaudreault, E et al; TAK1 contributes to the enhanced responsiveness of LTB4-treated neutrophils to Toll-like receptor ligands. Int. Immunol 2012, 24: 693 8. Imamura, Y et al; Salivary histatin 3 inhibits heat shock cognate protein 70-mediated inflammatory cytokine production through toll-like receptors in human gingival fibroblasts. J Inflamm 2014, 11: 4 |
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