PIAS1+PIAS2+PIAS3 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | PIAS1+PIAS2+PIAS3 |
| Clone | monoclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.03 mg, 0.1 mg, 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation |
| Immunogen | Immunogen: A synthesized peptide derived from human PIAS1+PIAS2+PIAS3. Subcellular Localization: Nucleus speckle. Nucleus, PML body. Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton. Tissue Specificity: Expressed in numerous tissues with highest level in testis. |
| Other Names | [E3 SUMO-protein ligase PIAS1; 6.3.2.-; DEAD/H box-binding protein 1; Gu-binding protein; GBP; Protein inhibitor of activated STAT protein 1; RNA helicase II-binding protein; PIAS1; DDXBP1], [PIAS1] |
| Gene, Accession # | [PIAS1+PIAS2+PIAS3], Gene ID: 8554, NCBI: NP_001307616.1, UniProt: O75925 |
| Catalog # | MBS179723 |
| Price | $160, $340, $340 |
| Order / More Info | PIAS1+PIAS2+PIAS3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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