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Antigenic Specificity | Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) |
Clone | [SPM595] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, kappa |
Format | CF555 conjugate |
Size | 0.5 mL |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma. |
Immunogen | Immunogen: A recombinant fragment containing amino acids 511-580 of human glypican-3 |
Other Names | [DGSX; Glypican proteoglycan 3; GPC3; GTR2-2; Heparan sulphate proteoglycan; Intestinal protein OCI-5; MXR7; OCI-5; SDYS; Secreted glypican-3; SGBS1] |
Gene, Accession # | [GPC3], Gene ID: 2719, NCBI: NP_001158091.1, UniProt: P51654 |
Catalog # | MBS4380943 |
Price | $340 |
Order / More Info | Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Yan, B., et al. 2011. Ann. Diagn. Pathol. 15: 162-169. |