Calprotectin, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Calprotectin, Human |
| Clone | 27E10 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 0.05 mg |
| Concentration | 100ug/ml |
| Applications | Immunohistochemistry Frozen (IHC-F), Immunofluorescence (IF), Flow Cytomertry (FC), Immuno Assay (IA), Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody 27E10 recognizes an epitope specific for the S100A8/A9 heterocomplex that is not exposed on the individual subunits S100A8 (MRP8, calgranulin-A) or S100A9 (MRP14, calgranulin-B). The calcium-binding migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process. The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages a |
| Immunogen | Immunogen: Human blood monocytes. Cross reactivity: Mouse |
| Other Names | n/a |
| Gene, Accession # | NCBI: AAB33355.1 |
| Catalog # | MBS584259 |
| Price | $465 |
| Order / More Info | Calprotectin, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Zwadlo, G et al; A monoclonal antibody to a subset of human monocytes found only in the peripheral blood and inflammatory tissues. J Immunol 1986, 137: 512 2. Hessian, P et al; The heterodimeric complex of MRP-8 (S100A8) and MRP-14 (S100A9) - Antibody recognition, epitope definition and the implications for structure. Eur J Biochem 2001, 268: 353 3. Kuhn, A et al; Upregulation of epidermal surface molecule expression in primary and ultraviolet-induced lesions of lupus erythematosus tumidus. Br J Dermatol 2002, 146: 801 4. Champaiboon, C et al; Calprotectin S100A9 calcium-binding loops l and ll are essential for keratinocyte resistance to bacterial invasion. J Biol Chem 2009, 284: 7078 |
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