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Antigenic Specificity | PUF60 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis inducti |
Immunogen | Immunogen: Recombinant Human Poly(U)-binding-splicing factor PUF60 protein (302-413AA) |
Other Names | [Poly(U)-binding-splicing factor PUF60; 60 kDa poly(U)-binding-splicing factor; FUSE-binding protein-interacting repressor; FBP-interacting repressor; Ro-bind; PUF60; FIR; ROBPI; SIAHBP1] |
Gene, Accession # | [PUF60], Gene ID: 22827, NCBI: NP_001129505.1, UniProt: Q9UHX1 |
Catalog # | MBS7051376 |
Price | $160, $235 |
Order / More Info | PUF60 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |