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Antigenic Specificity | BMI-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | IgG concentration 1.0mg/ml |
Applications | Immunohistology Frozen, Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti BMI-1 antibody recognizes 37kDa polycomb complex protein BMI-1, involved in segment specification, cell growth and maintenance, transcriptional regulation and chromatin modification. BMI-1 is a proto-oncogene which cooperates with the myc oncogene to produce B-lymphomas. It is required in the regulation of normal adult and leukaemic stem cells, making BMI-1 a potential target for stem cell proliferation and anti-cancer therapies. BMI-1 represses transcription at the ink4 locus which contains tumour suppressors p16 and p19Arf. BMI-1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex which ubiquitinates histone-2A at lys119, resulting in a heritable change in the ability of chromatin to express genes. BMI-1 is al |
Immunogen | Immunogen: 15 amino acid peptide sequence near the centre of human BMI-1. Buffer Solution: Phosphate buffered saline Antiserum Preparation: Antisera to human BMI-1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Human |
Other Names | [COMMD3-BMI1 read-through protein; Polycomb complex protein BMI-1; COMMD3-BMI1 read-through protein; COMMD3-BMI1 readthrough; Polycomb group RING finger protein 4; RING finger protein 51], [COMMD3-BMI1; BMI1; PCGF4; RNF51] |
Gene, Accession # | [BMI-1], Gene ID: 100532731, NCBI: NP_001190991.1, UniProt: P35226 |
Catalog # | MBS221477 |
Price | $375 |
Order / More Info | BMI-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |