BMI-1 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityBMI-1
Clonepolyclonal
Host SpeciesRabbit
Reactive Speciesmouse, rat
Isotypen/a
Formatunconjugated
Size0.1 mg
ConcentrationIgG concentration 1.0mg/ml
ApplicationsImmunohistology Frozen, Western Blot (WB)
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DescriptionRabbit anti BMI-1 antibody recognizes 37kDa polycomb complex protein BMI-1, involved in segment specification, cell growth and maintenance, transcriptional regulation and chromatin modification. BMI-1 is a proto-oncogene which cooperates with the myc oncogene to produce B-lymphomas. It is required in the regulation of normal adult and leukaemic stem cells, making BMI-1 a potential target for stem cell proliferation and anti-cancer therapies. BMI-1 represses transcription at the ink4 locus which contains tumour suppressors p16 and p19Arf. BMI-1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex which ubiquitinates histone-2A at lys119, resulting in a heritable change in the ability of chromatin to express genes. BMI-1 is al
ImmunogenImmunogen: 15 amino acid peptide sequence near the centre of human BMI-1. Buffer Solution: Phosphate buffered saline Antiserum Preparation: Antisera to human BMI-1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. Target Species: Human
Other Names[COMMD3-BMI1 read-through protein; Polycomb complex protein BMI-1; COMMD3-BMI1 read-through protein; COMMD3-BMI1 readthrough; Polycomb group RING finger protein 4; RING finger protein 51], [COMMD3-BMI1; BMI1; PCGF4; RNF51]
Gene, Accession #[BMI-1], Gene ID: 100532731, NCBI: NP_001190991.1, UniProt: P35226
Catalog #MBS221477
Price$375
Order / More InfoBMI-1 Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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