Edit |   |
---|---|
Antigenic Specificity | ERAB |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | Size: 100 ug/200 ul |
Applications | Immunohistology |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody reacts with human. The other species are not tested. Mutations in several genes associated with early onset Alzheimer's result in increased extracellular concentrations of the longer form of the beta-amyloid peptide Ab 1-42 relative to Ab 1-40. It is this longer form of Ab that has been shown to be toxic to neurons and may serve as a catalyst for the aggregation and deposition of Ab to produce the neurotoxic effects associated with senile plaque formation. Using the Ab peptide in a yeast two-hybrid screen, a novel interacting protein designated the endoplasmic reticulum-associated amyloid betapeptide-binding protein (ERAB)/L-3-hydroxyacyl-CoA dehydrogenase type II has been identified. It is shown to be expressed at high levels |
Immunogen | Antigen Preparation: A synthetic peptide corresponding to aa 100-116 of human ERAB protein. |
Other Names | n/a |
Gene, Accession # | [ERAB] |
Catalog # | MBS462183 |
Price | $270 |
Order / More Info | ERAB Antibody from MYBIOSOURCE INC. |
Product Specific References | He, X.Y., et al., J. Biol. Chem., 273, 10741 (1998). |