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Antigenic Specificity | KRT8 |
Clone | [AT3D11] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG3, k |
Format | Protein A purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1mg/ml |
Applications | ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that in human is encoded by the KRT8 gene. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been f |
Immunogen | Immunogen: Recombinant human KRT8 (1-483aa) purified from E. coli |
Other Names | [Keratin type II cytoskeletal 8; Keratin; type II cytoskeletal 8; keratin 8; CARD2; CK-8; CK8; CYK8; K2C8; K8; KO], [KRT8; KRT8; K8; KO; CK8; CK-8; CYK8; K2C8; CARD2; CYK8; CK-8; K8] |
Gene, Accession # | [KRT8], Gene ID: 3856, NCBI: NP_002264, UniProt: P05787 |
Catalog # | MBS200222 |
Price | $240, $315 |
Order / More Info | KRT8 Antibody from MYBIOSOURCE INC. |
Product Specific References | Moriya, T., et al. (2006) Med Mol Morphol 39 (1): 8-13; Leitner, A., et al. (2012) Biophys J 18;103 (2): 195-201 |