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Antigenic Specificity | BRE |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Componen |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 51-229 of human BRE (NP 954661.1). |
Other Names | [BRE; BRCC4; BRCC45; BABAM2] |
Gene, Accession # | [BRE], Gene ID: 9577, NCBI: NP_001248769.1, UniProt: Q9NXR7 |
Catalog # | MBS8549774 |
Price | $280 |
Order / More Info | BRE Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |