TNF-RII, Mouse Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-TNF-RII, Mouse antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | TNF-RII, Mouse |
| Clone | FITC |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2a |
| Format | fluorescein (FITC) conjugate |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | F, Flow Cytometry (FC/FACS), FS, Immuno Assay (IA), Immunoprecipitaion (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody HM102 recognizes the extracellular part of membrane-bound TNF-RII as well as the soluble form of TNF-RII which is generated by proteolytic cleavage of the extracellular domain. The soluble form can still bind TNF-alpha with high affinity and functions as a TNF-alpha antagonist. TNF-alpha is an important signalling protein in the immune system which can activate inflammatory responses, induce apoptosis, regulate cellular proliferation, and may even promote cancer progression. TNF-alpha can bind to two structurally distinct membrane receptors, TNF-RI and TNFRII, which have both distinct and overlapping downstream signaling cascades. TNFRI is believed to be expressed on nearly all cell types, wherea |
| Immunogen | n/a |
| Other Names | [Tumor necrosis factor receptor superfamily member 1B, CD120b, TNF-R2, p75, p80 TNF-alpha receptor], [TNFRSF1B; TNF-RII/TNFRSF1B; TNF-RII/TNFRSF1B] |
| Gene, Accession # | [TNF-RII], Gene ID: 338033, NCBI: ADU17359.1 |
| Catalog # | MBS584057 |
| Price | $730 |
| Order / More Info | TNF-RII, Mouse Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Tacchini-Cottier, F et al; Role of TNFR1 and TNFR2 in TNF-induced platelet consumption in mice. J Immunol 1998, 160: 6182 2. Brekke, O et al. Specificity of endogenous fatty acid release during tumor necrosis factor-induced apoptosis in WEHI164 fibrosarcoma cells. J of Lipid res. 1999, 40:2223 3. Marchetti, L et al; Tumor Necrosis Factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. J Biol Chem 2004, 279: 32869 4. Taoufik, E et al; FLIPL protects neurons against in vivo ischemia and in vitro glucose deprivation-induced cell death. J Neurosci 2007, 27: 6633 5. Veroni, C et al; Activation of TNF receptor 2 in microglia promotes induction of anti-inflammatory pathways. Mol Cell Neurosci 2010, 45: 234 6. Chee, J et al. TNF receptor 1 deficiency increases regulatory T cell function in nonobese diabetic mice. J immunol 2011, 187:1702-1712 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
Return to Antibodies