Edit |   |
---|---|
Antigenic Specificity | Mouse LPAM-1 |
Clone | [2G18] |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2 |
Format | Protein A purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) - Paraffin, Flow Cytometry (FC/FACS), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody was selected for its ability to detect mouse CD45 positive leukocytes in IHC. The antibody is specific for a combinatorial determinate of integrin alpha4beta7complex. Integrin alpha4beta7 is composed of a 150 kD (alpha4 or CD49d) and a 130 kD (beta7) heterodimer, also known as CD49d/beta7 or LPAM-1. Belonging to the Ig superfamily, it is found on the majority of peripheral lymphocytes and subsets of thymocytes and bone marrow cells (including mast cell progenitors). Integrin alpha4beta7 binds its ligands, VCAM-1 (CD106), MAdCAM-1 and fibronectin, and plays an important role in lymphocytes adhesion and the direction of migration of blood lymphocytes to the intestine and associated lymphoid tissues. |
Immunogen | Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with cell lysates of mouse lymphocytes. IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography. |
Other Names | [mouse LPAM-1 (#2G18)], [Itgb7; Itgb7; Ly69] |
Gene, Accession # | [LPAM-1], Gene ID: 16421, NCBI: NP_038594.2, UniProt: P26011 |
Catalog # | MBS690598 |
Price | $490 |
Order / More Info | Mouse LPAM-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |