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Antigenic Specificity | DOCK7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed: 16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). |
Immunogen | Immunogen: Recombinant human Dedicator of cytokinesis protein 7 protein (1440-1671AA) |
Other Names | [Dedicator of cytokinesis protein 7; DOCK7; KIAA1771] |
Gene, Accession # | [DOCK7], Gene ID: 85440, NCBI: NP_001258928.1, UniProt: Q96N67 |
Catalog # | MBS7050783 |
Price | $160, $235 |
Order / More Info | DOCK7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |