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Antigenic Specificity | CHRNB2 - middle region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | cow, dog, guinea pig, human, mouse, porcine, rat |
Isotype | n/a |
Format | Protein A purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This is a rabbit polyclonal antibody against CHRNB2. It was validated on Western Blot and immunohistochemistryTarget Description: Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy. Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CHRNB2 |
Other Names | [neuronal acetylcholine receptor subunit beta-2; Neuronal acetylcholine receptor subunit beta-2; neuronal acetylcholine receptor subunit beta-2; cholinergic receptor nicotinic beta 2 subunit] |
Gene, Accession # | [CHRNB2], Gene ID: 1141, NCBI: NP_000739, UniProt: P17787 |
Catalog # | MBS3202381 |
Price | $290 |
Order / More Info | CHRNB2 - middle region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |