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Antigenic Specificity | TBC1D1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 22 amino acid peptide from near the carboxy terminus of human TBC1D1. |
Other Names | [TBC1 domain family member 1, TBC, TBC1] |
Gene, Accession # | [TBC1D1], Gene ID: 23216, NCBI: NP_055988 |
Catalog # | MBS9407837 |
Price | $320 |
Order / More Info | TBC1D1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |