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Antigenic Specificity | ERK 8 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: ERK 8 Polyclonal Antibody detects endogenous levels of ERK 8 protein. The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions. |
Immunogen | Immunogen: Synthesized peptide derived from the internal region of human ERK 8 at AA rangle: 330-410 |
Other Names | [Rabbit ERK 8; MAPK15; ERK7; Mitogen-activated protein kinase 15; MAP kinase 15; MAPK 15; Extracellular signal-regulated kinase 7; ERK-7; Extracellular signal-regulated kinase 8; ERK-8] |
Gene, Accession # | [ERK8], Gene ID: 225689, NCBI: NP_620590.2, UniProt: Q8TD08 |
Catalog # | MBS9704885 |
Price | $130, $220, $325 |
Order / More Info | ERK 8 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |