Edit |   |
---|---|
Antigenic Specificity | DOK4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [DOK4; docking protein 4; FLJ10488; Insulin receptor substrate 5; IRS5; IRS 5], [DOK4; DOK4; IRS-5; IRS5] |
Gene, Accession # | [DOK4], Gene ID: 55715, NCBI: Q8TEW6.2, UniProt: Q8TEW6 |
Catalog # | MBS125627 |
Price | $200, $275, $430 |
Order / More Info | DOK4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |