Edit |   |
---|---|
Antigenic Specificity | SHARPIN - middle region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together wit |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SHARPIN |
Other Names | [sharpin; Sharpin; sharpin; SHANK associated RH domain interactor; Shank-associated RH domain-interacting protein; Shank-interacting protein-like 1] |
Gene, Accession # | [SHARPIN], Gene ID: 81858, NCBI: NP_112236.3, UniProt: Q9H0F6 |
Catalog # | MBS3222451 |
Price | $335 |
Order / More Info | SHARPIN - middle region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |