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Antigenic Specificity | TNFSF10 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/ |
Immunogen | Immunogen: A synthetic peptide of human TNFSF10 (NP 003801.1). |
Other Names | [tumor necrosis factor ligand superfamily member 10 isoform 2; Tumor necrosis factor ligand superfamily member 10; tumor necrosis factor ligand superfamily member 10; TNF superfamily member 10; Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand] |
Gene, Accession # | [TNFSF10], Gene ID: 8743, NCBI: NP_001177871.1, UniProt: P50591 |
Catalog # | MBS8567223 |
Price | $280 |
Order / More Info | TNFSF10 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |