Phospho-MLKL (S358) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-MLKL (S358) |
| Clone | 6F8 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | immunogen affinity purified |
| Size | 0.03 mL, 0.1 mL, 0.2 mL |
| Concentration | 1 mg/ml |
| Applications | Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: phospho-MLKL (S358) protein detects endogenous levels of MLKL. MLKL (mixed lineage kinase domain like) belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of MLKL inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript |
| Immunogen | Immunogen: Synthetic Peptide of phospho-MLKL (S358) |
| Other Names | [Mouse phospho-MLKL (S358) Mouse (6F8)] |
| Gene, Accession # | [MLKL], Gene ID: 197259, NCBI: NP_001135969.1, UniProt: Q8NB16 |
| Catalog # | MBS9700548 |
| Price | $130, $220, $325 |
| Order / More Info | Phospho-MLKL (S358) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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