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Antigenic Specificity | CDw17 (Lactosylceramide or LacCer) |
Clone | [HuLy-m13] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgM |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes, granulocytes, basophils, platelets, a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17, which can then mediate signaling toward PECAM-1 expression and angiogenesis. Tumor necrosis factor a (TNFa)-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal |
Immunogen | Immunogen: beta-2 Microglobulin associated proteins from a detergent lysate of human PBL |
Other Names | n/a |
Gene, Accession # | [CDw17] |
Catalog # | MBS438654 |
Price | $190, $340, $340 |
Order / More Info | CDw17 (Lactosylceramide or LacCer) Antibody from MYBIOSOURCE INC. |
Product Specific References | Lovering, K.E. Characterisation of the Tcell surface by monoclonal antibodies. PhD thesis, University of Melbourne, 1985. Knapp W. Leukocyte Typing IV, Oxford Univ. Press, pp. 810811, 1989. Also data on M119, pp 861, 874, 877 879, 897, 907, 923, 925 |