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Antigenic Specificity | beta-Catenin |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | mouse, rat, human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of N-terminal residues of beta-Catenin. beta-Catenin is a multifunctional adaptor protein involved in cadherin-mediated cell-cell adhesion and in responding to the activation of several signal transduction pathways. CK1 phosphorylates beta-catenin on Ser45. This phosphorylation event primes beta-catenin for subsequent phosphorylation by GSK-3. GSK-3beta destabilizes beta-catenin by phosphorylating it at Ser33, Ser37 and Thr41.). Mutations in beta-Catenin have been implicated in its accumulation and various forms of carcinomas. |
Immunogen | n/a |
Other Names | [catenin beta-1; Catenin beta-1; catenin beta-1; catenin (cadherin associated protein), beta 1; Beta-catenin], [Ctnnb1; Ctnnb1; Bfc; Mesc; Catnb; Catnb] |
Gene, Accession # | Gene ID: 12387, NCBI: NP_001159374.1, UniProt: Q02248 |
Catalog # | MBS857332 |
Price | $280 |
Order / More Info | beta-Catenin Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Kikuchi A.; Regulation of beta-catenin signaling in the Wnt pathway.; Biochem. Biophys. Res. Commun. 2.8:2.3.2.8(2.00). Dobrosotskaya I.Y., James G.L.; MAGI-1.interacts with beta-catenin and is associated with cell-cell adhesion structures.; Biochem. Biophys. Res. Commun. 2.0:903.909(2.00). |