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Antigenic Specificity | MCL1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | 1mg/mL |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mcl-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway (1). Similar to other Bcl-2 family members, Mcl-1 localizes to the mitochondria (2), interacts with and antagonizes pro-apoptotic Bcl-2 family members (3), and inhibits apoptosis induced by a number of cytotoxic stimuli (4). Mcl-1 differs from its other family members in its regulation at both the transcriptional and post-translational level. First, Mcl-1 has an extended amino-terminal PEST region, which is responsible for its relatively short half-life (1, 2). Second, unlike other family members, Mcl-1 is rapidly transcribed via a PI3K/Akt |
Immunogen | Immunogen: C term -peptide of human MCL1 Observed Molecular Weight: 37kDa |
Other Names | [MCL1; BCL2L3; EAT; MCL1L; MCL1S; MGC104264; MGC1839; Mcl-1; TM] |
Gene, Accession # | [MCL1], Gene ID: 4170, NCBI: AAD13299.1 |
Catalog # | MBS2518452 |
Price | $150, $225, $360 |
Order / More Info | MCL1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |