CD80 / B7-1 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | CD80 / B7-1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Cluster of Differentiation 80 (CD80), also called B-lymphocyte activation antigen B7-1 (formerly referred to as B7), is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. The B7-related molecules CD80 and CD86 are expressed on antigen-presenting cells, bind the homologous T cell receptors CD28 and CTLA-4, and trigger costimulatory signals important for optimal T cell activation. All four molecules are immunoglobulin superfamily members, each comprising an extracellular Ig variable-like (IgV) domain, with CD80 and CD86 containing an additional Ig constant-like (IgC) domain.1 The upregulation of B7-1 in podocytes may contribute to the pathogenesis of proteinuri |
| Immunogen | Immunogen: A synthetic peptide (conjugated to KLH) corresponding to extracellular region of human CD80 / B7-1. |
| Other Names | [CD80 / B7-1], [LOC554317] |
| Gene, Accession # | [CD80 / B7-1], Gene ID: 554317, NCBI: NP_001020134.1 |
| Catalog # | MBS355088 |
| Price | $275 |
| Order / More Info | CD80 / B7-1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Peach, R J; Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, Linsley P S (Sep. 1995). Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28. J. Biol. Chem. (UNITED STATES) 270 (36): 21181-7. 2. Reiser, J., von Gersdorff, G., Loos, M., Oh, J., Asanuma, K., Giardino, L., Rastaldi, M. P., Calvaresi, N., Watanabe, H., Schwarz, K., Faul, C., Kretzler, M., Davidson, A., Sugimoto, H., Kalluri, R., Sharpe, A. H., Kreidberg, J. A., Mundel, P. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J. Clin. Invest. 113: 1390-1397, 2004. |
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MYBIOSOURCE INC.
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