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Antigenic Specificity | KRT17 |
Clone | [AT9F3] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a, k |
Format | Protein A purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1 mg/ml |
Applications | ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments. Keratin 17 is involved in wound healing and cell growth, two processes that require rapid cytoskeletal remodeling. Keratinocytes deficient in keratin 17 exhibit abnormal Akt/mTOR signaling and fail to produce an increase in translation, cell size, or growth; these cells also exhibit abnormal 14-3-3 sigma localization. |
Immunogen | Immunogen: Recombinant human KRT17 (1-432aa) purified from E. coli |
Other Names | [Keratin type I cytoskeletal 17; Keratin; type I cytoskeletal 17; K17; PC; PC2; PCHC1], [KRT17; KRT17; PC; K17; PC2; 39.1; CK-17; PCHC1; CK-17; K17] |
Gene, Accession # | [KRT17], Gene ID: 3872, NCBI: NP_000413, UniProt: Q04695 |
Catalog # | MBS200354 |
Price | $240, $315 |
Order / More Info | KRT17 Antibody from MYBIOSOURCE INC. |
Product Specific References | Kim S., et al. (2006) Nature. 441 (7091): 362-365; Troyanovsky S.M., et al. (1992) Eur J Cell Biol. 59 (1): 127-137; McGowan K.M. and Coulombe P.A. (1998) J Cell Biol. 143 (2): 469-486 |