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Antigenic Specificity | IRAK-M |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: IRAK-M antibody has no cross response to IRAK or IRAK2. Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M. IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cyto |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a peptide corresponding to amino acids from the carboxy terminus of human IRAK-M. |
Other Names | [Homo sapiens IL-1 receptor-associated-kinase-M mRNA, complete cds; Interleukin-1 receptor-associated kinase 3; interleukin-1 receptor-associated kinase 3; interleukin-1 receptor-associated kinase 3; IL-1 receptor-associated kinase M; IRAK-M] |
Gene, Accession # | [IRAK-M], Gene ID: 11213, NCBI: AF113136 |
Catalog # | MBS9407217 |
Price | $320 |
Order / More Info | IRAK-M Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |