RNF20 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | RNF20 |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.05 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates |
| Immunogen | n/a |
| Other Names | [Purified Mouse (Mab); E3 ubiquitin-protein ligase BRE1A; BRE1-A; hBRE1; 632-; RING finger protein 20; RNF20; BRE1A] |
| Gene, Accession # | [RNF20], Gene ID: 56254, NCBI: NP_062538.5, UniProt: Q5VTR2 |
| Catalog # | MBS9216855 |
| Price | $165, $370 |
| Order / More Info | RNF20 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Wu H.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. Ota T.,et al.Nat. Genet. 36:40-45(2004). Humphray S.J.,et al.Nature 429:369-374(2004). Bechtel S.,et al.BMC Genomics 8:399-399(2007). Zhu B.,et al.Mol. Cell 20:601-611(2005). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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