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Antigenic Specificity | C-RAF (Phospho-Ser642) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of C-RAF only when phosphorylated at serine 642. Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of Serine 642(T-T-S(p)-P-R) derived from Human C-RAF. |
Other Names | [C-RAF; C-Raf; CRAF; RAF-1] |
Gene, Accession # | [C-RAF], Gene ID: 5894, NCBI: NP_002871.1, UniProt: P04049 |
Catalog # | MBS9402624 |
Price | $200, $255 |
Order / More Info | C-RAF (Phospho-Ser642) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |