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Antigenic Specificity | CD79a (IGBP1) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | Protein G purified |
Size | 0.1 mg, 0.2 mg |
Concentration | n/a |
Applications | Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD79 is a dimeric transmembrane protein that is associated with membrane immunoglobulin and initiates B-cell signaling following engagement of the latter by antigen.1-3 The 2 component chains of CD79, referred to as CD79a and CD79b. CD79a as well as CD79b is purported to be a B cell-specific antigen. CD79a expression begins at the earliest pro-B stage of development and continues throughout Bcell differentiation to the plasma cell stage,6 making it one of the most useful pan-B-cell markers used in routine immunophenotypic analysis. In addition, CD79a expression seems to be restricted to B-lineage cells (ie,a diagnostically specific B-cell marker). |
Immunogen | Source Note: Polyclonal CD79a antibody was produced from sera of rabbits immunized with synthetic protein containing CD79a antigenic determinants. |
Other Names | [Rabbit Human CD79 purified; IGBP-1; IGBP1; cd79; cd-79;; PAb], [CD79A; IGA; MB1] |
Gene, Accession # | [CD79], Gene ID: 973, NCBI: NP_001774.1, UniProt: P11912 |
Catalog # | MBS551050 |
Price | $280, $385 |
Order / More Info | CD79a (IGBP1) Antibody from MYBIOSOURCE INC. |
Product Specific References | • b cell depletion with anti-CD79 mabs ameliorates autoimmune disease in mrl/lpr mice.J. Immunol., Sep 2008; 181: 2961 - 2972. • antibody-drug conjugates targeted to CD79 for the treatment of non-hodgkin lymphoma.Blood, Jul 2007; 110: 616 - 623. • antibody-drug conjugates targeted to CD79 for the treatment of non-hodgkins lymphoma.Blood (ASH Annual Meeting Abstracts), Nov 2006; 108: 2524. • CD79 alpha/CD79 beta heterodimers are expressed on pro-b cell surfaces without associated mu heavy chain.Int. Immunol., Nov 1997; 9: 1767 - 1772. |