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Antigenic Specificity | CBL |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b,k |
Format | unconjugated |
Size | 0.05 mL, 0.2 mL |
Concentration | 0.98 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This CBL antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 450-644 amino acids from human CBL. Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. P |
Immunogen | n/a |
Other Names | [E3 ubiquitin-protein ligase CBL; 6.3.2.-; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL; CBL; CBL2; RNF55; Purified Mouse (Mab)] |
Gene, Accession # | [CBL], Gene ID: 867, NCBI: P22681.2, UniProt: P22681 |
Catalog # | MBS9217325 |
Price | $165, $370 |
Order / More Info | CBL Antibody from MYBIOSOURCE INC. |
Product Specific References | Blake T.J.,et al.Oncogene 6:653-657(1991). Taylor T.D.,et al.Nature 440:497-500(2006). Howlett C.J.,et al.Biochem. Biophys. Res. Commun. 257:129-138(1999). Joazeiro C.A.,et al.Science 286:309-312(1999). Donovan J.A.,et al.J. Biol. Chem. 269:22921-22924(1994). |