C5aR, Mouse Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | C5aR, Mouse |
| Clone | 20/70 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2b |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC), FS, Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody 20/70 recognizes the mouse receptor for C5a (CD88). The mouse anaphylatoxin complement factor C5a, a split product of C5, is one of the most potent inflammatory chemoattractants and interacts with two C51 receptors, C5aR and C5L2.- Most of the C5a effects are mediated through C5aR. C5aR is known to be crucial in the initiation of acute inflammatory responses. C5a receptor is a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 45 kDa C5a receptor is expressed by leukocytes such as neutrophils, eosinophils, basophils, monocytes, dendritic cells and mast cells. C5aR can be expressed on both immune and nonimmune cells. Nonimmune cells express |
| Immunogen | Immunogen: RBL-2H3 transfectantsexpressing murine C5aR on the cell surface. |
| Other Names | n/a |
| Gene, Accession # | [C5aR] |
| Catalog # | MBS584113 |
| Price | $720 |
| Order / More Info | C5aR, Mouse Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Shushakova, N et al; C5a anaphylatoxin is a major regulator of activating versus inhibitory FcγRs in immune complex-induced lung disease. J Clin Invest 2002, 110: 1823 2. Soruri, A et al; Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody. Immunol Lett 2003, 88: 47 3. Godau, J et al; C5a initiates the inflammatory cascade in immune complex peritonitis. J Immunol 2004, 173: 3437 4. Chen, NJ et al; C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature 2007, 446: 203 5. Rittirsch, D et al; Functional roles for C5a receptors in sepsis. Nat Med 2008, 14: 551 6. Gueler, F et al; Complement 5a Receptor inhibition improves renal allograft survival. J Am Soc Nephrol 2008, 19: 2302 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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