DTNBP1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DTNBP1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Dysbindin, or dystrobrevin-binding protein 1, is a coiled-coil-containing protein expressed in muscle and brain that was identified as a binding partner of dystrobrevin (1). Dysbindin upregulates expression of the pre-synaptic proteins SNAP25 and synapsin I, thereby increasing glutamate release and promoting neuronal viability through Akt signaling. In particular, Akt phosphorylation is suppressed with downregulation of dysbindin and increased with upregulation of dysbindin (2). A nonsense mutation of dysbindin causes Hermansky-Pudlak disease, an autosomal recessive disorder characterized by lysosomal storage defects and prolonged bleeding. (2). Genetic variation in the gene encoding dysbindin is strongly associated with schizophrenia and p |
| Immunogen | Immunogen: Recombinant protein of human DTNBP1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [DBND; DKFZp564K192; FLJ30031; HPS7; MGC20210; My031; SD] |
| Gene, Accession # | [DTNBP1], Gene ID: 84062, NCBI: NP_001258596.1, UniProt: Q96EV8 |
| Catalog # | MBS8505694 |
| Price | $310 |
| Order / More Info | DTNBP1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Benson, M.A. et al. (2001) J Biol Chem 276, 24232-41. 2. Numakawa, T. et al. (2004) Hum Mol Genet 13, 2699-708. 3. Straub, R.E. et al. (2002) Am J Hum Genet 71, 337-48. 4. Talbot, K. et al. (2004) J Clin Invest 113, 1353-63. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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