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Antigenic Specificity | TRIM2 |
Clone | polyclonal |
Host Species | Goat |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TRIM RING finger protein TRIM2, a ubiquitin ligase, is highly expressed in the nervous system. It binds to neurofilament light subunit (NF-L);and regulates NF-L ubiquitination. Deficiencies in TRIM2 increases NF-L level in axons and NF-L-filled axonal swellings in cerebellum, retina, spinal cord, and cerebral cortex. These deficiencies eventually lead to neurodegeneration, tremors and ataxia. It is proposed that TRIM2 has neuroprotection properties. |
Immunogen | Immunogen: Peptide with sequence DSGNHCFKVYRYLQ, from the C Terminus of the TRIM2 protein sequence according to NP_056086.2; NP_001123539.1 |
Other Names | [tripartite motif-containing protein 2 isoform 1; Tripartite motif-containing protein 2; tripartite motif-containing protein 2; tripartite motif containing 2; E3 ubiquitin-protein ligase TRIM2; RING finger protein 86], [TRIM2; TRIM2; CMT2R; RNF86; KIAA0517; RNF86] |
Gene, Accession # | [TRIM2], Gene ID: 23321, NCBI: NP_056086.2, UniProt: Q9C040 |
Catalog # | MBS555931 |
Price | $440 |
Order / More Info | TRIM2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |