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Antigenic Specificity | Phospho-IRF-3 (Ser385) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-IRF-3 (Ser385) antibody detects endogenous levels of IRF-3 only when phosphorylated at Serine 385. Description: IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP.Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a |
Immunogen | Immunogen: A synthesized peptide derived from human IRF-3 around the phosphorylation site of Serine 385 Subcellular Location: Cytoplasm. Nucleus. Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm. Tissue Specificity: Expressed constitutively in a variety of tissues. Predicted Cross Reactivity: Pig, Bovine, Sheep, Dog Similarity: Pig (92%), Bovine (92%), Sheep (92%), Dog |
Other Names | [IIAE7; Interferon regulatory factor 3; IRF 3; IRF-3; IRF3; IRF3_HUMAN; MGC94729] |
Gene, Accession # | [IRF-3], Gene ID: 3661, NCBI: NP_001184051.1, UniProt: Q14653 |
Catalog # | MBS9601207 |
Price | $240, $280 |
Order / More Info | Phospho-IRF-3 (Ser385) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |