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Antigenic Specificity | ATXN7L3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: ATXN7L3 antibody detects endogenous levels of total ATXN7L3. Function: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoub |
Immunogen | Immunogen: A synthesized peptide derived from human ATXN7L3 Subcellular Location: Nucleus. Predicted Cross Reactivity: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken Similarity: Pig (100%), Zebrafish (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (100%) |
Other Names | [AT7L3_HUMAN; Ataxin 7 like 3; Ataxin 7 like protein 3; Ataxin-7-like protein 3; atxn7l3; SAGA associated factor 11 homolog; SAGA-associated factor 11 homolog] |
Gene, Accession # | [ATXN7L3], Gene ID: 56970, NCBI: NP_001092303.1, UniProt: Q14CW9 |
Catalog # | MBS9609552 |
Price | $240, $280 |
Order / More Info | ATXN7L3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |